Kyoto University Hospital creates pancreatic islet cells from IPS cells for diabetes clinical trials, with the hope of eliminating the need for insulin injections.

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0001100cm horse mackerel★.Sep. 2, 2024 (Mon) 18:31:44.70ID:wfLtfQor9
For patients with type 1 diabetes, whose pancreatic cells do not function normally, Kyoto University Hospital will begin clinical trials to create pancreatic islet cells, a type of pancreatic tissue, from IPS cells from healthy people, and then transplant these sheets into patients. *For more information, please see the following source.
9/2 (Mon) 11:56
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0016Anonymous Donburako.Sep. 2, 2024 (Mon) 18:40:47.43ID:yTVrO9Df0
>>1
Is type 1 diabetes unrelated to poor lifestyle habits?
0030Anonymous Donburako.Sep. 2, 2024 (Mon) 18:51:11.22ID:7SXuEzD90
>>1
However, in the future, when a revolutionary new diabetes treatment is developed and kidney transplants become unnecessary, will our neighbors start to get involved and tell us not to interfere with their business?
0002Anonymous Donburako.Sep. 2, 2024 (Mon) 18:33:00.62ID:G39Nz8Wq0
It seems that IPS-related stuff only progresses to a certain point.
0004Anonymous Donburako.Sep. 2, 2024 (Mon) 18:34:43.44ID:4c0P8Ue10
Since pancreas transplants are not possible, are they planning to repair it?
0006Anonymous Donburako.Sep. 2, 2024 (Mon) 18:35:29.52ID:IQkDWcFX0(1/3)
It’s easy to make but difficult to prevent it from becoming cancerous.
0007Anonymous Donburako.Sep. 2, 2024 (Mon) 18:36:41.94ID:htgH3Rgk0(1/2)
Even children have type 1 so this is pretty big news.
0008Anonymous Donburako.Sep. 2, 2024 (Mon) 18:37:47.84ID:WvA7T8Zq0
They do this because they’ve confirmed regeneration in animals, but I still can’t believe it actually increases normal cells?!
0010Security Guard [lv.4] [Sprout].Sep. 2, 2024 (Mon) 18:37:57.81ID:8/Bm/hcY0(1/4)
It would be great if we could donate the entire pancreas when we had pancreatic cancer and receive an IPS pancreas transplant.
0012Security Guard [lv.4] [Sprout].Sep. 2, 2024 (Mon) 18:38:35.23ID:8/Bm/hcY0(2/4)
>>10
× Submit
○ Remove.
0011Anonymous Donburako.Sep. 2, 2024 (Mon) 18:38:34.96ID:ql7w+Xpt0
Do I need immunosuppressants? I don’t know what they are, but will I have to take them for the rest of my life?
0014Security Guard [lv.4] [Sprout].Sep. 2, 2024 (Mon) 18:40:31.14ID:8/Bm/hcY0(3/4)
>>11
This news article says that they are made from IPS cells from healthy people,
but I think that if IPS cells are made from the individual’s own somatic cells,
it should be possible to avoid the immune system.
0015Anonymous Donburako.Sep. 2, 2024 (Mon) 18:40:35.71ID:G11xJvWb0
>>11
Which is more troublesome, insulin or steroids?
0022Anonymous Donburako.Sep. 2, 2024 (Mon) 18:45:43.24ID:X7xTLw2v0(2/2)
>>14
Autologous iPS is too costly
We are creating a bank so that allogeneic iPS can be engrafted without immunosuppressants by managing the immune type well.
0017Security Guard [lv.4] [Sprout].Sep. 2, 2024 (Mon) 18:41:27.90ID:8/Bm/hcY0(4/4)
If you have type 1 diabetes, you’ll probably still be taking immunosuppressants.
0047! donguri.Sep. 2, 2024 (Mon) 19:05:33.22ID:2XbUs4590
>>17
Is it caused by autoimmune destruction of the pancreatic islets?
0018Security guard [lv.35].Sep. 2, 2024 (Mon) 18:42:50.62ID:LMuTK1yU0(1/2)
Type 1 is a genetic or autoimmune disease.

Regenerative medicine or transplant alternatives?

Isn’t there a dramatic recovery?

0019Anonymous Donburako.Sep. 2, 2024 (Mon) 18:43:23.87ID:DKLZzGYQ0(2/2)
Are you not the overeating pig?
0020Anonymous Donburako.Sep. 2, 2024 (Mon) 18:44:47.17ID:wI+UR8wk0
Only wealthy acquaintances are saved.
0027Anonymous Donburako.Sep. 2, 2024 (Mon) 18:47:24.12ID:2PTUKvre0
>>20
Seriously? (tot)
0021Anonymous Donburako.Sep. 2, 2024 (Mon) 18:45:27.08ID:NXWyzsva0
Give me your kidneys. Not needing dialysis would be a huge benefit. Diabetes can still be controlled with insulin.
0023Anonymous Donburako.Sep. 2, 2024 (Mon) 18:45:56.67ID:8E63k3Q30
Type 2 is spoiled.
0024Anonymous Donburako.Sep. 2, 2024 (Mon) 18:46:16.02ID:htgH3Rgk0(2/2)
It would be nice if it only required dietary restrictions.
0025Anonymous Donburako.Sep. 2, 2024 (Mon) 18:46:20.60ID:gg90JUCf0
I won’t believe in IPS until the mountains are covered in thick fur.
0026Anonymous Donburako.Sep. 2, 2024 (Mon) 18:46:27.77ID:nyc1tQ5+0
The B cells in the islets of Langerhans are the ones that are messed up, so it’s only IDDM.
In the case of nidDM, insulin is produced in abundance, but the problem lies with the receptor, so even IPS cells can’t do anything about it.
0028Anonymous Donburako.Sep. 2, 2024 (Mon) 18:47:59.20ID:y4mxCjBH0
Will artificial dialysis disappear?
0036Anonymous Donburako.Sep. 2, 2024 (Mon) 18:54:58.01ID:O07VkaaW0
>>28
It’s the pancreas, not the kidneys.
0029Security guard [lv.27].Sep. 2, 2024 (Mon) 18:49:34.57ID:Oy1o+qao0
Those with type 2 should pay for it themselves.
0037Security guard [lv.35].Sep. 2, 2024 (Mon) 18:55:07.88ID:LMuTK1yU0(2/2)
>>30
I hope that by then, evil commercialism will be defeated and the world will value human rights.
It was after the war that commercialism (capitalism) tried to take away capital and profit prospects in various places by using force to make things the common property of the people and oppressing those who wanted it…
0031Anonymous Donburako.Sep. 2, 2024 (Mon) 18:51:40.08ID:nbPDi3fA0
It’s scary to hear about a retired baseball player who had type 2 diabetes and a small wound on his leg that became increasingly infected and nearly required amputation.
0034Anonymous Donburako.Sep. 2, 2024 (Mon) 18:54:39.31ID:IQkDWcFX0(2/3)
>>31
It’s scary, but if it gets that bad, even if your leg doesn’t rot, you’ll only have a few years left to live.
0039Anonymous Donburako.Sep. 2, 2024 (Mon) 18:58:11.69ID:tRu7Yf8M0(1/3)
>>31
Sano had his toes and right arm amputated due to severe lower limb ischemia, he had chronic kidney failure and required dialysis, and he had repeated heart failure and valvular heart disease.
0032Guard [lv.45].Sep. 2, 2024 (Mon) 18:52:28.00ID:i/6W+3iu0
Type 1?
0033Anonymous Donburako.Sep. 2, 2024 (Mon) 18:53:27.73ID:CVNeFKxH0
IPS is amazing.
0068Anonymous Donburako.Sep. 2, 2024 (Mon) 19:58:47.78ID:AMFag2WX0
>>33
You will be able to use your own cells for organ transplants. Don’t live to be 100 years old. Life is so long, what you do with your life becomes an issue.
0035Anonymous Donburako.Sep. 2, 2024 (Mon) 18:54:50.92ID:vQcdaiDZ0
If this becomes a popular success, it could be a Nobel Prize win.
0038Anonymous Donburako.Sep. 2, 2024 (Mon) 18:55:23.64ID:SJ/EPnLq0(1/2)
For now, please let my hair grow back, there’s nothing I can do about it.
0045Anonymous Donburako.Sep. 2, 2024 (Mon) 19:03:34.49ID:gRZQc+2I0(2/2)
>>38
>Hair
Researchers say that treatment will be available in about 5 years.
However, it is not covered by insurance, so it will likely cost at least several million at first.
0040Anonymous Donburako.Sep. 2, 2024 (Mon) 18:58:45.87ID:gRZQc+2I0(1/2)
The island that everyone has but no one can reach is called the Islet of Langerhans.
0044Anonymous Donburako.Sep. 2, 2024 (Mon) 19:02:52.15ID:tRu7Yf8M0(2/3)
It is not a scary disease as long as it is detected early, blood sugar is controlled, and complications are avoided.
0050Anonymous Donburako.Sep. 2, 2024 (Mon) 19:07:08.49ID:tRu7Yf8M0(3/3)
If hyperglycemia continues for many years and causes blood vessels to become damaged, complications will develop and progress, no matter how well blood sugar is controlled.
0054Anonymous Donburako.Sep. 2, 2024 (Mon) 19:12:08.32ID:gY+M3bJR0
This would be big news if it were successful, but we don’t always hear results.
Reference: https://asahi.5ch.net/test/read.cgi/newsplus/1725269504

Other languages: 京都大学病院が“糖尿病治験”へiPS細胞から膵島細胞を作製「インスリン注射不要」への期待, El Hospital Universitario de Kioto está preparando células de los islotes pancreáticos a partir de células IPS para “ensayos clínicos sobre diabetes” y espera “no necesitar inyecciones de insulina”.

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